For any anti-inflammatory disease, there are a variety of medicines available. One of the newer, more popular medicines on the market for anti-inflammatory diseases is Humira, though it does have some side effects.
Also known as adalimumab, Humira was formulated on April 1, 1995 by the Cambridge Antibody Technology and BASF Knoll Aktiengesellschaft. Humira treats such diseases as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, juvenile idiopathic arthritis, and psoriasis.
Humira works by controlling a substance called TNFa in your body. Tumor necrosis factor’s role in your body is the regulation of immune cells. Tumor Necrosis Factor (TNF) causes a process known as apoptotic cell death (programmed cell death) to inhibit the viral replication and tumorigenesis that results in inflammation.
Humira can control inflammation by stopping TNFa from activating its receptors. While Humira does prevent TNFa from activating its receptors, it can create some side-effects that may be serious for the individual prescribed this drug. The main side effect of Humira is that a person can become more prone to infections and viruses when taking the medicine.
Because TNF plays a vital role in your immune system when Humira inhibits it from completing its job, your health system becomes more unguarded to infections. This “openness” can reactivate tuberculosis and allow for blood disorders that sometimes lead to death. Other rare side-effects of Humira include solid tissue cancers, lymphoma, serious liver injury, demyelinating central nervous system disorders, and cardiac arrest. As a result of these side effects, the FDA has issued a black-box warning requiring doctors to screen potential patients before prescribing Humira.
Despite the possible negative effects that Humira can have on your health, it does have a strong history of providing people with inflammatory disorders, such as arthritis and Crohn's, the chance to go into remission. When in remission, these affected individuals can enjoy a normal life.